Can IgA class IV be controlled for life? IgA nephropathy is a pathological classification that refers to glomerulonephritis caused by IgA deposition in the glomerular thylakoid zone, which is the most common type of primary glomerulonephritis, most often manifested as hematuria. According to the degree of pathological damage it can be divided into five grades, where IgA4 grade refers to patients with diffuse cellular proliferation and deposition of matrix in the glomerular thylakoid area, about 45% of glomeruli will sclerosis, a relatively more serious type, the patient may have renal failure exists. For patients with kidney damage this damage is often irreversible, and the treatment in the clinic is to slow down the process of chronic kidney damage, but not to cure it completely. Therefore, it is not easy to say that IgA grade IV can be controlled for life, but regular review, following medical advice and good lifestyle habits are helpful to control the disease.