There are two ways to lower creatinine: 1, internal treatment: internal treatment is to give evidence-based treatment of Chinese medicine and proprietary Chinese medicine, such as Chinese medicine Huang Lian Wen Bile Tang and Qing Fei Fei Defeated Poison Drink, as well as proprietary Chinese medicine Haikun Kidney Xi Capsule, Renal Failure Ning Tablets, Urotoxic Qing Granules, etc.; 2, external treatment: external treatment includes artificial colon dialysis, as well as machine method colon dialysis, Chinese medicine retention enema, acupuncture point compress, laser therapy, etc. When the condition reaches the end stage of uremia, there are artificial replacement therapy, hemodialysis, peritoneal dialysis, and also kidney transplantation. When the condition reaches the end stage of uremia, there are artificial replacement therapy, hemodialysis, peritoneal dialysis, and also kidney transplantation. If high creatinine is caused by acute renal failure, after removing aggravating factors, such as malignant hypertension, renal blood volume deficiency, infection, drug-related kidney injury, which cause the aggravating factors of creatinine increase, creatinine can be decreased and most patients finally return to normal.