High glutamate dehydrogenase is handled differently according to different causes, physiological causes usually do not need special treatment, pathological causes can be treated with hepatoprotective therapy, such as taking glycyrrhizic acid preparation, and treating the primary disease, such as entecavir anti-hepatitis B virus, and so on. 1. Physiological causes: strenuous exercise, overwork, staying up late, drinking alcohol and so on can lead to the elevation of glutamate dehydrogenase, physiological elevation needs light diet, rest, abstinence from alcohol and so on, no special treatment is needed. 2. Pathologic causes: (1) Hepatoprotective treatment: apply hepatoprotective drugs, common ones are detoxification, hepatocyte membrane repair, choleretic, antioxidant, improve hepatocyte energy metabolism, such as ursodeoxycholic acid, glycyrrhizic acid preparations, and so on. (2) Treatment of primary diseases: viral hepatitis needs antiviral treatment such as entecavir; alcoholic hepatitis needs alcohol cessation; drug liver injury needs drug cessation or drug change; fatty liver needs weight and blood lipid control, etc. In addition, cirrhosis and hepatocellular carcinoma also need to be treated. In addition, cirrhosis and hepatocellular carcinoma may also cause glutamate dehydrogenase elevation, which requires active treatment of the primary disease. If you have elevated glutamate dehydrogenase, it is recommended that you consult a doctor in time to determine the cause of the disease and then follow the doctor’s instructions to carry out targeted treatment to avoid adverse consequences.