Low estradiol is not necessarily a case of premature ovarian failure. If a patient has a sex hormone panel 6 and folliculopoietin and luteinizing hormone are rising and estradiol is falling, for this case, it is low estradiol due to ovarian failure. It can also be seen in patients with central amenorrhea, who can also have low estradiol. The ovaries of such patients are normal, and if they have fertility requirements, pregnancy is possible with the application of ovulation-promoting drugs. The six sex hormones FSH, follicle stimulating hormone, and LH, luteinizing hormone, are both low, as is estrogen, and such patients also need hormone replacement therapy to maintain their health.