Pericardial effusion is not a contraindication for the Neocoronavirus vaccine. Pericardial effusion is a contraindication for the inactivated vaccine, and patients with pericardial effusion often have symptoms of pallor, dyspnea, and chest tightness, which may be aggravated by injection of pericardial effusion vaccine. Therefore, patients with pericardial effusion are advised not to receive the new crown vaccine, but to wait until the disease has healed to avoid adverse effects on their health. Pericardial effusion patients need to identify the specific cause of the disease, and then targeted treatment to prevent further development of the disease, if the patient has symptoms of cardiac tamponade, the need for urgent pericardiocentesis drainage surgery, and need to give nutritional support to encourage a high-protein, high-calorie diet.