A fifteen-year-old patient with severe lumbar spondylolisthesis was recently seen, breaking the misconception of many sufferers about the age limit of lumbar spondylolisthesis; in fact, lumbar spondylolisthesis can occur at any age, and is best in middle-aged women aged 40-60, and is common in the 4th and 5th lumbar spine. The reasons for this are mainly the following: first of all, it is caused by intervertebral disc degeneration, due to intervertebral disc dehydration and degeneration, which reduces its volume and narrows the corresponding vertebral space, resulting in the relaxation of the anterior and posterior longitudinal ligaments. When the spine flexes, extends and flexes laterally, the normal movement of the vertebral body cannot be restrained, resulting in excessive anterior, posterior or lateral displacement of the upper vertebral body, causing pseudo-slip of the vertebral body. Next is the muscle ligament chronic strain injury: often occurs in muscle activity or static posture in the part of the muscle lasting tension. Due to sedentary, standing or lumbar sustained a certain action and make the lumbar, sacroiliac ligament muscle long-term tension, greatly exceed its own load and aseptic inflammatory exudation, sclerosis, muscle ligament loss of elasticity and toughness, followed by biomechanical imbalance, resulting in vertebral instability, the emergence of vertebral displacement. There are also endocrine disorders in middle-aged women: such as endocrine changes after menopause, some will make the ligaments and joint capsule elasticity weakened, relaxation, followed by lumbar spondylolisthesis, so women after menopause is more common. Finally, the abnormal bone structure: especially the lumbar spine, pelvis, lower limb bone deformity or fracture deformity healing, resulting in spinal mechanics imbalance and secondary vertebral instability displacement, lumbar spine curvature abnormalities, the emergence of vertebral body slippage. Middle-aged women suffer from lumbar spondylolisthesis in addition to chronic strain causes, there is an important reason is the poor pelvic recovery after pregnancy, breastfeeding and childbirth. As we age, the level of estrogen also gradually decreases, bone metabolism slows down, bone strength decreases, and isthmic fractures are more likely to occur. The combination of these factors leads to a significantly higher incidence of lumbar isthmus fracture in middle-aged women compared to other populations, making them susceptible to lumbar spondylolisthesis. Therefore, women should pay more attention to the scientific use of the waist, in the premise of a balanced diet and sun bathing, but also diligent practice, diligent protection, diligent conditioning, to prevent the occurrence of lumbar spondylolisthesis. The treatment of lumbar spondylolisthesis also needs to vary from person to person, to do the necessary examination, to find a professional doctor treatment is the best way, acupuncture massage heat therapy and other ways to reduce the pain, but also need professional medical guidance to carry out, so as not to aggravate the symptoms.