The skull may be hard, but it is still difficult to resist some strong external impacts. Many people suffer from cranial defects due to accidents, which not only puts the brain tissue under great threat from the outside world, but also affects the aesthetic image. Therefore, when encountering the misfortune of cranial defects, it is necessary to go to the regular hospital, through the cranial bone repair surgery to save. Nowadays, cranial bone repair has become a relatively routine procedure in neurosurgery, and the technique has become very mature, with a high degree of surgical safety. However, although technically there is no longer any problem, there is another factor that restricts the effectiveness of the surgery, and that is the choice of repair material. After all, it is to be placed into the body, especially located in the head, related to the function of the brain and the normal operation of the organs of the head and face, so cranial bone repair must choose a good material. At present, the more widely used clinical material is titanium mesh material, but titanium mesh repair skull rejection is an inevitable problem. Because titanium mesh, a metal material, is more different from human tissue, the tissue compatibility is not particularly ideal, so some patients will have a rejection reaction. Titanium mesh repair skull rejection occurred should do? Therefore, we avoid blindly choosing materials and bring serious harm to the body. Currently, the clinical application of a new type of polyether ether ketone PEEK material as cranial bone repair material. This PEEK material can successfully overcome the problem of titanium mesh repair cranial bone rejection. This PEEK material has very good histocompatibility and basically has no rejection reaction. In addition, it has excellent performance in other aspects, very close to the human autologous skull, successful cranial bone repair of the latest trend.