Polymethylsulfonyl may refer to polymethylsulfonyl suppositories or polymethylsulfonyl gel, which are mainly used for the treatment of vaginitis and are administered for 6 consecutive days as a course of treatment. However, the duration of use should be extended according to the type of pathogenic infection, the patient’s specific clinical manifestations, and the sensitivity of the medication to achieve a complete clinical cure. Polymethylsulfonyl is an antiseptic and antiseptic agent. Its mechanism of action is to destroy pathogenic microorganisms through strong acid and protein coagulation to achieve therapeutic effect. If polymethylsulfonyl is used for a short period of time, the efficacy cannot be guaranteed, and long-term use is likely to cause adverse reactions, such as local burning, itching, occasional pain and increased secretion. During the course of treatment, necrotic material may fall off and vaginal secretions may be discharged with the drug residue, which is a normal phenomenon and represents the effect of the drug to treat the disease. During the treatment of polymethylphenol sulfonamide, sexual intercourse should be avoided, the vulva should be washed and kept clean and dry, spicy, greasy and stimulating food should be avoided, and bed rest is recommended to ensure sufficient sleep to help the recovery of the disease.