Chronic atrophic gastritis with intestinal metaplasia can be treated with antacids, gastric mucosal protectants, gastric motility drugs, etc., and if combined with Helicobacter pylori, quadruple therapy can be used for eradication. 1. Chronic atrophic gastritis is a gastric disease in which the intrinsic glands of the gastric mucosa are atrophied, with or without intestinal metaplasia. If it is accompanied by intestinal metaplasia, it can be treated with gastric mucosal protectants such as colloidal bismuth, bismuth potassium citrate, etc., and gastric motility drugs such as domperidone and mosapride. 2. If chronic atrophic gastritis is combined with Helicobacter pylori infection, it needs to be eradicated by using quadruple therapy, and commonly used drugs include omeprazole, clarithromycin, amoxicillin, bismuth potassium citrate and so on. Patients with severe heterozygous hyperplasia can also be treated with endoscopic surgery. Regular gastroscopy should be performed on a daily basis, and medication should be administered as prescribed by the doctor. If there is any discomfort, please consult the doctor in time.