Hashimoto’s hypothyroidism generally refers to Hashimoto’s thyroiditis combined with hypothyroidism, which can be considered to be treated with medications such as levothyroxine and prednisone. Hashimoto’s thyroiditis is an autoimmune disease of the thyroid gland that progresses with symptoms of hypothyroidism and goiter, such as weakness, fatigue, chills, bradycardia, bloating, and constipation. When Hashimoto’s thyroiditis is combined with clinical or subclinical hypothyroidism, levothyroxine can be taken as prescribed by the doctor for replacement therapy, and regular checkups are needed after taking the medication to maintain the thyroid hormone within a reasonable range. Prednisone can be considered for rapid enlargement of the thyroid gland with localized pressure and pain. Patients diagnosed with Hashimoto’s thyroiditis combined with hypothyroidism should actively cooperate with the doctor’s treatment and take medication under the doctor’s guidance.