Lumps and hardness on the face can be caused by acne, boils and folliculitis, and are treated with anti-inflammatory drugs. 1. Acne is a common skin disease during puberty and is also a chronic inflammatory skin disease, which can be improved by taking antibiotics and applying topical keratolytic drugs, such as oral doxycycline hydrochloride tablets and topical adapalene gel. 2. Skin boil is an inflammation that occurs in the deep part of the hair follicle, due to the deeper part of the lesion, so in the early stage of the disease is mainly manifested in the subcutaneous appearances of the obvious pressure and pain sensation of the mass, in the treatment of the oral anti-inflammatory mainly, for example, amoxicillin capsule, roxithromycin capsules, and so on. 3. Folliculitis is an acute infectious disease, due to shallow lesions, in the treatment of topical drugs, such as topical mupirocin cream. Due to the influence of many factors, the specific situation needs to first ask the doctor for an interview, and then choose the treatment plan.