Glutamate dehydrogenase is found mainly in the mitochondria of the body, generally in the human liver, kidneys and heart, and for the brain and skeletal muscle, some blood cells still have glutamate dehydrogenase components. In general, glutamate dehydrogenase is measured to assess the diagnosis of liver disease in patients. Glutamate dehydrogenase is elevated in patients with acute or chronic viral hepatitis, autoimmune hepatitis, or cirrhotic liver fibrosis. The activity of glutamate dehydrogenase is significantly higher and the amount of glutamate dehydrogenase is increased after hepatocyte necrosis or liver dysfunction, and after mitochondrial damage. Patients who have been drinking alcohol or taking medications for a long time may also have elevated glutamate dehydrogenase. If elevated glutamate dehydrogenase is present, and if it is present on two consecutive reviews, we should actively look for the cause, see if the patient has viral hepatitis and if he has been drinking alcohol for a long time, and, if necessary, require intravenous infusion of liver-protective drugs for liver preservation.