Glutamate dehydrogenase is a particularly sensitive indicator of liver function in clinical practice, and a high level of glutamate dehydrogenase indicates varying degrees of liver damage. Glutamate dehydrogenase is the most abundant enzyme in the human liver, so the main cause of high glutamate dehydrogenase is damage to liver cells. Glutamate dehydrogenase is most sensitive when reflecting alcoholic liver cell injury, because alcohol-induced liver cell injury is mainly caused by damage to mitochondria in liver lobular cells, where most of the glutamate dehydrogenase is found. Therefore, liver injury, such as acute hepatitis, viral hepatitis, liver fibrosis, toxic hepatitis, and cirrhosis are all causes of elevated glutamate dehydrogenase.