The cause of the leg nerve compression needs to be clarified, the clinical often seen disc herniation on the sciatic nerve compression, pear-shaped muscle inflammation on the sciatic nerve compression. The nerve root edema can be improved with oral or IV medications, such as Diosmin, Herbacetin, and Myclobutanil, or with IV mannitol, and if necessary, hormonal medications, such as dexamethasone and methylprednisolone. If necessary, hormonal drugs such as dexamethasone and methylprednisolone can be added. Nutritional nerve therapy, such as methylcobalamin and vitamin B1, can also be combined with traction for herniated discs to reduce the pressure on the sciatic nerve and relieve clinical symptoms. If conservative treatment is ineffective, surgical decompression is feasible. It can also be seen in the post-traumatic compression of the common peroneal nerve and the tibial nerve, which originates from direct violence, but also from the compression of the muscle by soft tissue edema. If there is no obvious injury, mannitol with hormones can be administered, if the drugs are not effective, incision and decompression are feasible, and if the EMG is significantly abnormal, incision and exploration anastomosis are feasible.