AIDS is the end stage of human immunodeficiency virus (HIV) infection. With anal fissures there is a risk of transmitting HIV, infectiousness is related to the viral infection and effective protection can help reduce the risk. Human immunodeficiency virus (HIV) is a group of viruses that can be transmitted through blood and body fluids. When infected, it affects the function of the body’s immune T-cells and makes the body immunocompromised. AIDS develops when the infection is uncontrolled and the virus replicates in large numbers at the end stage. Anal fissure is a disease in which the entire skin of the anal opening is broken, and contact with this area during the attack may cause bleeding. If you have sex (especially anal sex) during an anal fissure episode, you may expose both partners to the risk of various sexually transmitted diseases, including HIV. Although the risk of HIV transmission can be reduced by controlling HIV load with oral medications and using protection such as condoms, strenuous sexual activity such as anal sex during anal fissure is not recommended to avoid complications. At the same time, there is still no effective cure for HIV infection, and once diagnosed, life-long medication is required to control the infection, and virological tests should be performed as soon as possible to confirm the diagnosis.