The causes of small particles on both sides of the cheeks include keratosis pilaris, eczema, folliculitis, warts, etc. Treatment includes medication and physical therapy. 1. Keratosis pilaris: due to genetic factors triggering excessive keratinization of the lower end of the funnel part of the hair follicle, so the phenomenon of small particles on both sides of the cheeks, at this time you need to give topical adapalene gel, oral vitamin A, isotretinoin, and other medications to exfoliate the treatment. 2. Eczema: due to a variety of internal and external factors triggering inflammation of the dermis and epidermis, thus triggering the skin to grow small particles, at this time can be given to apply glucocorticoid ointment such as dinexed ointment, calcium-regulated phosphatase inhibitors such as pimecrolimus ointment and other drug therapy. 3. Folliculitis: due to fungal or bacterial infections, you can use topical antifungal drugs such as ketoconazole lotion, antibiotics such as fusidic acid and other drugs. 4. Warts: due to human papilloma virus infection caused by small particles, then you can give the application of 5% imiquimod ointment to get rid of the treatment. Or take physical therapy such as liquid nitrogen cryotherapy. Finally, the phenomenon of small particles on both sides of the cheeks, please consult a doctor in a timely manner, the above drugs must follow the doctor’s instructions.