Sleeping in the middle of the night left chest pain may be due to coronary atherosclerotic heart disease, reflux esophagitis and other causes of the situation, need to treat the cause. 1. Coronary atherosclerotic heart disease: mainly due to coronary artery atherosclerosis resulting in narrowing of the lumen, the patient may experience coronary artery spasm during sleep, resulting in abnormal blood supply to the myocardium, resulting in the symptom of left chest pain, you can use nifedipine controlled release tablets and other drugs to treat. 2. reflux esophagitis: may be due to the patient in the night sleep, the cardia of the stomach is not completely closed, so that the gastric acid reflux into the esophagus, caused by the left chest vaguely distension, may also appear heartburn symptoms, can use omeprazole enteric-coated capsules and other drugs to treat. If you are sleeping in the middle of the night, you should follow the doctor’s instructions to use medication in daily life, eat a light diet, and consult a doctor when the symptoms are not relieved.