Melasma is a symmetrical yellow-brown pigmentation spot on the face, which is common among young and middle-aged women. There are general treatments, medications and laser treatments to get rid of melasma, and there is no such thing as the best way to remove melasma. 1. General treatment: avoid triggering factors, such as avoiding sunlight exposure, applying external shading agent and correctly choosing and using cosmetics when going out in spring and summer seasons; avoiding hormone or photosensitive drugs, such as avoiding drugs that cause hormone level changes and photosensitive drugs, and so on. 2. Drug treatment: including external drug treatment, such as decolorant, can use 2% ~ 5% hydroquinone cream, 4% tretinoin, 15% ~ 20% azelaic acid cream and other drug treatment; systemic drug treatment, such as oral drugs, vitamin E can be anti-lipid peroxidation, oral vitamin C can inhibit melanin synthesis. Vitamin C and vitamin E combined treatment is more effective. 3. Laser treatment: Picosecond and ultra-picosecond lasers have certain therapeutic effect on melasma, but it needs several times of treatment. There is no such thing as the best way to remove chloasma. Patients should go to the hospital in time to find out the cause of the disease and treat it actively so as not to delay the condition.