Hepatitis B E antigen is normally less than 1.0 COL and appears to be 4.17 COL using anti-hepatitis B virus medication may transform into hepatitis B minor triple positive or hepatitis B minor bi-yang, which can be converted to negative. Hepatitis B E antigen is the third of the five items of hepatitis B test, is the number of hepatitis B virus replication markers, normally negative, positive suggests the existence of the number of active viral replication, persistent positive suggests that the liver cell damage is more serious, it may be easy to become chronic susceptible to hepatitis or cirrhosis, suggesting that the infectiousness is greater. Hepatitis B E antigen positivity alone is rare in hepatitis B virus infection, and the results of the other two halves of the test need to be evaluated. In particular, if the patient appears positive for hepatitis B surface antigen, testing for hepatitis B viral DNA is needed to determine the infectiousness and viral replication of hepatitis B in conjunction with quantitative hepatitis B E antigen testing. If the hepatitis B epidemic antigen is positive, and at the same time there is hepatitis B surface antigen positive, hepatitis B core antibody positive suggesting the existence of hepatitis B triple positive, the use of antiviral drugs may be transformed into hepatitis B minor triple positive, or even transformed into hepatitis B minor bi-prevalent, and the E antigen is turned into negative. For patients who are positive for hepatitis B E antibody, consult the department of infection in a regular hospital.