Hepatitis B Major Triple Positive to Minor Triple Positive means that the replication ability of Hepatitis B virus in the body is weakened and the infectiousness is gradually decreasing. Hepatitis B major triple positive usually means that the hepatitis B surface antigen, core antibody and e antigen are all positive in the hepatitis B half-pair test. Minor Triple Positive means that Hepatitis B surface antigen and core antibody show positive. When the e antigen turns negative there will be hepatitis B major triple positive to minor two positive. And e antigen is mainly distributed in the cell gap, more hidden, can exist in the core particles of soluble protein, is one of the signs of hepatitis B virus infection, may be related to viral replication. If the virus replication in the body is more active and the number is higher, it may suggest that the hepatitis B virus is more infectious. When hepatitis B triple positive turns into small double positive, it may mean that the hepatitis B virus is less active and the infectiousness gradually decreases. Hepatitis B patients should go to the hospital, complete the relevant examinations and use medication under the guidance of the doctor for treatment.