Erythrocyte osmotic fragility test is generally not diagnostic of anemia. Genetic analysis is needed to confirm the diagnosis of anemia, and Erythrocyte osmotic fragility test is only one of the auxiliary tests.
1. The results of erythrocyte osmotic fragility test are usually reduced in patients with anemia, but the results of erythrocyte osmotic fragility test are reduced in sickle cell anemia, iron deficiency anemia, obstructive jaundice, lead poisoning, pernicious anemia, after splenectomy, liver disease, etc. Therefore, this test can not be used as a confirmation of the diagnosis of anaemia, and it can only be used as an auxiliary examination.
2. Since anemia is an autosomal recessive hereditary disease, and genetic testing can detect diseases caused by genetic abnormalities and is usually more accurate, genetic testing is the gold standard for the diagnosis of anemia.
In addition, there are blood tests, bone marrow aspiration, hemoglobin electrophoresis, etc. The specific diagnosis and treatment should be carried out under the guidance of doctors.