Syphilis conversion also requires retesting, which needs to be done regularly for 2-3 years, according to guidelines.
After standardized treatment of syphilis, the titer of non-specific syphilis helical antibodies changes, which is a dynamic process that needs to be reviewed for 2-3 years according to the guidelines.
In the first year after treatment, syphilis serologic tests are reviewed every three months, and every six months starting in the second year (two years of follow-up for early syphilis and three years for late syphilis). If the titer recurs during retesting, such as a significant increase in titer (≥ two dilutions) or a change from negative to positive, re-treatment is required.
Syphilis is a sexually transmitted disease and should be treated promptly in a hospital dermatologic and venereal disease department with active treatment and regular follow-up. Sexual partners also need to be screened.