The Hepatitis B five indicators have now become a routine part of our health screening program, and it is very important for our clinicians to know how to correctly interpret the Hepatitis B five indicators. What are the five hepatitis B indicators? What is the clinical significance of the items? 1.HBsAg (surface antigen): previous infection or current HBV infection. 2.Anti-HBs (surface antibody): a protective antibody. 3, HBeAg (e antigen): an important sign of active replication and infectiousness of HBV. 4.Anti-HBe (e antibody): appears at the same time as anti-HBs, indicating that HBV replication is diminished. 5, anti-HBc (core antibody): low titer indicates past infection, high titer indicates active replication of HBV.