Typical symptoms of glomerulosclerosis include proteinuria, hematuria, edema, renal hypoplasia, etc. Other symptoms such as anemia, fatigue, hypertension, electrolyte disorders, etc. may also occur. 1. Typical symptoms: proteinuria, edema and hematuria are typical symptoms of glomerulosclerosis. Early proteinuria can be intermittent, with the progress of proteinuria can develop into persistent; with the increase of proteinuria can appear plasma protein drop and manifested as edema. Hematuria is often manifested as microscopic hematuria. 2. Other symptoms: after the decline of renal function, erythropoietin is reduced and anemia occurs; the increase of metabolic wastes in the body makes the body experience general discomfort such as fatigue and fatigue, and hydroelectrolyte disorders. Glomerulosclerosis can show different symptoms according to different causes. It is recommended that patients with glomerulosclerosis should consult the doctor in time and under the doctor’s guidance, actively treat the disease, control the risk factors such as blood pressure, blood glucose, blood lipids, etc., and have regular checkups to avoid further development of the disease.