Closed mouth acne refers to acne when the opening of the pore is blocked and the internal oil is not exposed to the air. It is a manifestation of acne lesions and can be treated with topical creams and chemical peels. 1. Topical creams: (1) Retinoic acid, which effectively exfoliates the skin and prevents dead skin and oil from clogging pores, thus reducing acne formation. Initial use may have a slight irritation, acute dermatitis, eczema and women in the first three months of pregnancy is prohibited. (2) Benzoyl peroxide, with oxidizing effect, can slowly release active oxygen, kill the number of bacteria on the skin. Skin dryness, flaking is the most common side effects, acute inflammation of the skin and those with breakouts are prohibited. 2. Chemical peeling: Through the use of chemicals (commonly used fruit acid and salicylic acid) acting on the skin to cause different levels of damage, inducing the reconstruction of the skin’s surface layer and dermal structure, for the removal of acne has obvious results. Temporary breakouts may occur after the procedure, and it is not recommended for patients with sensitive skin or dermatitis eczema. The appearance of closed mouth acne, it is recommended to go to the hospital in a timely manner, the above medication should be used in accordance with medical advice.