Age-related macular degeneration is a disease that endangers the health of the eyes of people over the age of 50. If you experience blurred vision, distorted vision, overall brightness loss, or dark shadows obscuring the center of vision, you may have wet age-related macular degeneration. In this case, you should visit the macular specialist in ophthalmology and undergo relevant tests, such as fundus fluorescence angiography and optical coherence tomography (OCT) to confirm the diagnosis of the disease. Wet age-related macular degeneration because there are newly grown blood vessels in the macula – choroidal neovascularization, the new blood vessels are prone to repeated bleeding and edema, which seriously affects the vision, if not treated, the vision will drop dramatically within 3 months, and 85% of patients will become blind within 2 years. So is there any way to treat wet age-related macular degeneration? What treatment methods are available? Which method of treatment is the most effective? What other methods can be used to treat this disease in the future? First of all, I would like to tell you that there is now a safe and effective treatment for wet AMD. Before that, the treatment methods of our fundus doctors were limited, there are the following treatment methods: 1. Oral Chinese medicine or western medicine: help the absorption of macular bleeding but can not stop the progress of the disease, now only used as an auxiliary treatment. 2. Thermal laser photocoagulation: In the 90s, laser photocoagulation appeared to close the neovascularization, which has certain effect. The disadvantage is that fewer patients are suitable for laser treatment, only for lesions far from the center of the macula; and there is damage to the surrounding normal tissue; and half of the patients will relapse after treatment. Nowadays, it is only applicable to a few patients who are suitable for treatment. 3. Trans-pupillary thermotherapy: compared with thermal laser, it has less damage to the surrounding normal tissues and strong penetration. It is suitable for lesions slightly far from the center of macula, which is more limited and not suitable for most of the lesions in the center of macula. 4.Cold laser – photodynamic therapy (PDT): It started in 2000, and our Beijing hospital was the first to carry out PDT treatment in China in 2001. It is through the input of a special photosensitive drug in the intravenous vessels, this drug and the macular neovascularization in the eye specific combination, and then through the laser irradiation of neovascularization, so that the neovascular occlusion, no longer bleeding, to achieve the role of closed blood vessels. pdt treatment has no damage to the surrounding normal tissues, can delay the loss of vision, a few patients vision improvement. It is still the preferred method for the treatment of wet age-related macular degeneration in 2001 to 2007. 5.Fundus surgery (vitreoretinal surgery): When the macula is freshly bleeding, intraocular gas injection or retinal incision and blood drainage are feasible to keep the bleeding away from the macula or discharge; if a lot of intraocular bleeding enters into the vitreous body to form vitreous accumulation of blood, vitrectomy surgery should be performed to absorb the accumulation of blood; or the lesion has reached an advanced stage and formed a scar, the lesion tissue can be removed surgically and functional fundus cells can be implanted at the same time. The macular transposition can also be performed to transfer the surrounding normal tissue to the macula. The above surgery has certain therapeutic effect. However, it requires high surgical skills of ophthalmologists, relatively large surgical risks and more complications. 6.Anti-neovascular treatment: breakthrough scientific progress, improve vision after treatment. 2006 anti-new blood vessel (VEGF) drugs for ophthalmic treatment was rated as the sixth of the world’s top ten scientific breakthroughs by the scientific journal. In 2007, Beijing Hospital was the first in China to carry out this treatment, and now has the largest number of cases treated and the most experience. To date, more than 4 million patients have been treated in over 100 countries worldwide and have received safe and effective treatment. This treatment has become the most effective treatment for wet age-related macular degeneration. The current treatment is based on anti-neovascular therapy, sometimes requiring a synergistic effect in combination with photodynamic laser therapy or in combination with intraocular gas injection for better results. In the future, there are more treatment options to look forward to. Intraocular injections currently under investigation have achieved better efficacy by combining with antineovascular treatment. In addition, by retaining the urine of patients with macular degeneration, the cells in it are extracted and transformed into retinal cells in the fundus in vitro, and finally transplanted into the macular lesion in the fundus to help vision recovery. We believe that in the near future, through the joint efforts of doctors and patients, there will be more and better treatment methods.