The recovery period for adverse skin reactions after discontinuation of retinoic acid cream is usually 1 to 3 weeks. Retinoic acid cream is a keratolytic agent and is commonly used clinically for the treatment of acne vulgaris, flat warts, and mucous membrane leukoplakia. When topical retinoic acid cream is applied topically, it may cause skin irritation such as burning, erythema, and flaking, which may make the lesions more noticeable, but it is not an exacerbation of the condition and usually indicates that the drug is working. In most cases, the skin adapts and tolerates the irritation and it gradually disappears. If the irritation persists or worsens, the medication may be suspended under medical supervision, and most patients return to normal within 1 to 3 weeks after stopping the use of retinoic acid cream. The use of retinoic acid cream should be under the guidance of a medical professional. Retinoic acid cream is contraindicated for women in the first 3 months of pregnancy, breastfeeding women, and those who are allergic to any of the components of this product.