In clinical practice, empty saddle surgery is not a craniotomy, but a minimally invasive surgery, called transsphenoidal saddle resection, but it must be judged according to the actual condition of the patient. The proportion of patients who have surgery for this disease state of empty saddle is relatively small, more often symptomatic treatment is given, oral medication can be improved, and rarely surgical treatment is needed. If surgery is really needed, the corresponding preparation must be carried out, sometimes it may induce cerebral hemorrhage, intracranial infection, cerebrospinal fluid leakage and a series of adverse reactions, so empty saddle surgery must be treated carefully, before surgery must improve the relevant examination, to clarify the specific changes in the condition, so that the surgery can be better and smoothly implemented.