Overexertion can lead to chest pain. When overexertion occurs, the body will be sympathetically overexcited, which will release too much renin-angiotensin-aldosterone system, which will cause the capillaries to contract violently, and patients will have unstable angina, especially for patients with a history of coronary heart disease, they will have chest pain with radiation-like symptoms to the back of the sternum. Patients who have a history of coronary artery disease should go to the hospital for an electrocardiogram in time to avoid acute coronary syndrome. In addition, for patients without previous history of coronary artery disease, overexertion may also cause damage to the heart muscle due to fatigue, after the damage to the heart muscle cells will also have clinical manifestations of chest pain, at this time should try to bed rest, can be appropriate to take certain nitrate drugs, observe the patient’s situation.