Chronic inflammation of mucosa with epithelial enterosis generally refers to chronic inflammation of gastric mucosa with intestinal epithelial hyperplasia, and the treatment methods include general treatment, drug treatment and surgery. 1. General treatment: maintain a light, easy-to-digest diet, avoid overeating, avoid eating spicy, irritating, cold and rough food. 2. Drug treatment: patients with Helicobacter pylori infection need to take quadruple therapy for treatment, such as pantoprazole, bismuth potassium citrate combined with amoxicillin and metronidazole. If accompanied by abdominal distension, early satiety and other symptoms can also be used to promote gastrointestinal dynamics drugs such as domperidone, mosapride and other treatment. 3. Surgery: if gastric cancer is induced by intestinal epithelial hyperplasia, surgery should be considered. In case of chronic inflammation of gastric mucosa with intestinal epithelial hyperplasia, it is recommended to go to the hospital for consultation and standardized treatment under doctor’s guidance.