A. Hepatitis B two-and-a-half general knowledge Hepatitis B “two-and-a-half” is a popular term, generally speaking from the medical academic, strictly called hepatitis B antigen antibody system test. Hepatitis B two-and-a-half is the most common serum marker used in domestic hospitals to check whether you are infected with the hepatitis B virus (HBV). The Hepatitis B 5 tests, also known as the Hepatitis B 2.5, include Hepatitis B surface antigen (expressed as HBsAg), Hepatitis B surface antibody (expressed as anti-HBS), e antigen (expressed as HBeAg), e antibody (expressed as anti-HBe), and core antibody (expressed as anti-HBc). The Hepatitis B 5 test is a serological marker that detects the hepatitis B virus in the blood by drawing venous blood from the patient. It is also known as the “Hepatitis B Five”. Because the hepatitis B “two pairs of half” the people can easily grasp, the people are also used to follow a piece called “big three yang”, “small three yang”, “two pairs of half “This is a common name for the public, but it is not allowed to be written in medical cases. Two-and-a-half refers to the five items, the first pair refers to have surface antigen and surface antibody. The second pair is the E antigen and E antibody. The “half” refers to the core antibody. The hepatitis B two-and-a-half is mainly a response to whether the body is infected with the hepatitis B virus, to fully understand the infection, to match the HBV-DNA test, so as to better reflect the real virus replication in the body. Second, the significance of the hepatitis B two to half test: 1) the first positive, the remaining four negative. This hepatitis B five test results indicate that it is the latent period of acute hepatitis B virus infection late; 2) the fifth positive, the remaining four negative. This means that the person is a recessive carrier of hepatitis B virus or is in the window stage of infection, and also indicates that he has been infected with hepatitis B virus; 3) the first three items are positive, and the remaining three items are negative. This hepatitis B five test result indicates an early stage of acute hepatitis B. 4) The first and fifth items are positive, and the remaining three items are negative. This hepatitis B test result indicates that the person has been infected with the hepatitis B virus and is recovering; 5) The first, third and fifth items are positive, and the remaining two items are negative. Commonly known as “major tri-positive”, this kind of hepatitis B five results indicate acute and chronic hepatitis B; 6) the first, fourth and fifth positive, the remaining two negative. This is commonly known as “small triplet”, indicating acute and chronic hepatitis B. 7) The fourth and fifth items are positive, and the remaining three items are negative. The five hepatitis B results indicate that the hepatitis B virus is recovering from acute hepatitis B infection or has been infected with the hepatitis B virus; 8) the second, fourth and fifth positive items, the remaining two negative items. It indicates a recovery period of hepatitis B with existing immunity; 9) The second and fifth items are positive, and the remaining three are negative. The hepatitis B five results indicate that it is after the hepatitis B vaccination, or the hepatitis B virus infection has recovered and has immunity. The general indications of hepatitis B antiviral: (1) HBV DNA ≥ 105 copies/ml (≥ 104 copies/ml for HBeAg negative); (2) ALT ≥ 2 × ULN; if treated with interferon, ALT should be ≤ 10 × ULN and total blood bilirubin level should be 2< span=""> × ULN; (3) if ALT < 2 × ULN, but liver histology shows Knodell HAI ≥4, or inflammatory necrosis ≥G2, or fibrosis ≥S2.