You cannot give up trying because glioma is hard to cure Glioma is hard to cure, but with aggressive and standardized treatment, it can significantly improve prognosis or long-term survival, especially if low-grade glioma does not progress to high-grade glioma, it will not affect life expectancy. There is hope with effort. Do not be enthusiastic about new therapies, thinking that new is good. Treat conventional therapies that have clear evidence of effectiveness correctly. New approaches are often exploratory treatments, often with unclear efficacy, so you cannot take it for granted that new is good. Conventional approaches are those that have been proven clearly effective through many years of clinical practice, and in the case of glioma, conventional treatments should be accepted first. The trial group of clinical trials also adds new methods to conventional methods. There are no new drugs available beyond phase III clinical practice. Do not overemphasize the status of surgery, postoperative radiotherapy treatment can not keep up, glioma is not a purely surgical disease, surgery alone can not cure. Therefore, postoperative treatment such as radiotherapy should be used as appropriate with a view to sustaining tumor control. Do not overemphasize radiotherapy and ignore surgery as the main treatment method. Among the many treatments for glioma, surgery is still the main treatment method and patients benefit most from surgery, and the probability of good prognosis without surgery is low. Imaging diagnosis of low-grade glioma may not necessarily have a good prognosis, but may also be a high-grade prognosis. Choosing to wait and see needs to be done with caution; non-enhancement is not necessarily a low-grade glioma, and some histology of low-grade glioma with molecular typing is a high-grade prognosis. If the situation allows, it is still necessary to cut more; expanded resection is likely to have a better prognosis, and the premise of safety is to cut more if you can, and to expand if you can, to benefit more. Therefore, the guidelines recommend maximum safe resection. Insula, thalamus, and brainstem gliomas are still more securely operated in large centers. Tumors in these areas are more surgically complex, demanding on the operator and platform, and require certain skills and surgical aids. Total resection is difficult and prone to complications. Choose carefully. The difference in prognosis between standardized and non-standardized glioma treatment is really a big pit, so it is good to avoid it.