Chronic hepatitis B should be standardized treatment, otherwise, the consequences are endless! 1, the general indications for antiviral treatment (1) HbeAg positive, HBV DNA ≥ 105 copies/ml (equivalent to 2000 IU/ml); HbeAg negative, HBV DNA ≥ 104 copies/ml (equivalent to 2000 IU/ml); (2) ALT ≥ 2 * ULN; such as treatment with interferon, ALT should be ≤ 10 * ULN, serum Total bilirubin should be < 2 * ULN; (3) ALT < 2 * ULN, but liver histology shows knodell HAI ≥ 4, or inflammatory necrosis ≥ G2, or fibrosis ≥ S2. 2, pregnant women: for newborns of HbsAg-positive mothers, hepatitis B immunoglobulin (HBIG) should be injected within 24h after birth (preferably 12h), and the dose should be R100 IU, while in Hepatitis B vaccination at different sites. 3. Newborns can receive breastfeeding from HbsAg-positive mothers within 12 hours after birth, hepatitis B immune globulin injection and hepatitis B vaccination.