Upper respiratory tract infection caused by sinusitis smell loss, you can choose antibiotics, glucocorticoid drugs, nasal rinsing and other methods of treatment.1. Antibiotics: if the upper respiratory tract infection caused by bacterial infection, you can take amoxicillin, cefuroxime, ofloxacin and other antibiotics for anti-infection treatment. 2. Hormonal drugs: the main choice of topical glucocorticoid nasal spray, such as mometasone furoate nasal spray, trimethoprim nasal spray, but also oral prednisone and other medications to reduce nasal mucosal swelling. 3. Nasal decongestant: applying 0.5%-1% ephedrine solution to the nose, applying not more than 7 days, contracting the nasal mucosa, exposing the mucosa of the olfactory region and improving the sense of smell. 4. Nasal rinsing: saline can be used for nasal rinsing, nasal secretions will be flushed out to improve nasal congestion, the sense of smell loss has a certain effect. Upper respiratory tract infection caused by sinusitis smell loss, it is recommended to go to the hospital in time to check, the drug under the guidance of the doctor.