Uric acid is produced and metabolized mainly by the liver, small intestine and kidneys after the breakdown of purine nucleotides, and is generally excreted in the urine. Nucleotides are the basic units of nucleic acids (i.e., DNA and RNA) and are divided into purine nucleotides and pyrimidine nucleotides, the former of which are metabolized to produce uric acid. Purine nucleotides are mainly metabolized in the liver, small intestine and kidneys. In the process of metabolism, purine nucleotides in the purine base is eventually broken down to generate uric acid, through the kidneys and excreted in the urine. When the intake of high-purine food (such as shrimp, crab and other seafood), the body due to disease caused by a large number of nucleic acid decomposition (such as leukemia, malignant tumors, etc.) or renal disease and make uric acid excretion obstacles, can lead to uric acid in the blood, resulting in hyperuricemia and even lead to the occurrence of gout. Therefore, it is recommended that patients with high uric acid should consult a doctor in a timely manner and follow the doctor’s instructions to complete the relevant examinations to clarify the diagnosis and standardize the diagnosis and treatment.