Vaccines are biological products made from various types of pathogenic microorganisms that are used for prophylactic inoculation. Vaccines made from bacteria or spirochetes are also known as bacteriophages. Vaccines are categorized into live and dead vaccines. Commonly used live vaccines include BCG, polio vaccine, measles vaccine, plague vaccine and so on. Commonly used dead vaccines are pertussis vaccine, typhoid vaccine, influenza vaccine, cholera vaccine and so on. The production time varies from vaccine to vaccine, and some may take up to 22 months to produce a single batch. The purpose of vaccination is to stimulate the production of specific antibodies in the body to fight against these viruses or pathogens that may be encountered in the future. No one lives in a vacuum, so vaccinations of all kinds help to boost one’s immunity and prevent the occurrence of various infectious diseases. However, which vaccines can chronic kidney disease patients receive? Generally speaking, daily life often encounters the risk of infections with pathogenic organisms such as hepatitis B virus, influenza and pneumococcus, which often induce kidney disease or trigger the reoccurrence of kidney disease, so vaccines against these pathogenic organisms are highly recommended by me for patients with chronic kidney disease. For patients with advanced kidney disease, especially those who have already received dialysis or transplantation, they need to be vaccinated because of their special condition, and the type and dosage of the vaccine must be under the guidance of specialists. Vaccines that are necessary for children’s growth, such as measles, mumps and rubella vaccine (MMR vaccine), should be given to all children, including patients with common kidney disease and dialysis; a single vaccination is usually sufficient for adults. Care should be taken to test antibody titers after vaccination. Cristal polio vaccine is generally indicated in patients with end-stage renal disease, but inactivated vaccine is required. Hepatitis A virus vaccine is an inactivated viral vaccine that is not recommended for all patients with chronic kidney disease, and is used in populations at increased risk of infection, such as those who travel to infected areas, those over 2 years of age who live in areas with a high prevalence of hepatitis, homosexuals, chronic liver disease, and coagulation disorders. Influenza vaccine should be used before the annual influenza season, live attenuated influenza vaccine should not be used, and inactivated influenza vaccine should be used. The 23-valent Streptococcus pneumoniae polysaccharide vaccine (PPV23) is recommended for use in immunocompromised adults who have pneumococcal disease or are at increased risk for complications (including chronic renal failure, nephrotic syndrome, and after renal transplantation). It should be emphasized that almost all vaccines for kidney disease can be used, but only “inactivated” vaccines should be used, and caution should be exercised with “attenuated” vaccines!