If there are blisters on the vulva that are itchy and painful, the most common clinical cause is due to herpes simplex virus infection, which is often a viral infection caused by a decrease in the body’s resistance. Not only is it itchy, but also painful when the blisters break. In addition to the local application of ribavirin ointment, if the pain is severe, you can take oral painkillers to relieve the symptoms. In addition, for the vulva with blisters, and itching, pain, in the clinical does not exclude the possibility of herpes zoster, mainly due to the body resistance, immunity decline, only to make the virus infection and lead to herpes zoster. The clinical strengthening of nutrition, improve immunity, and the local can apply acyclovir ointment, and recommended oral ribavirin for treatment, and pain serious oral ibuprofen for pain.