At night when sleeping with sore calves, there are usually several factors as follows: First, the most common factor is too much exercise the day before, or too much glycolysis in the body to release a large amount of ATP at the same time, it will lead to excessive lactic acid in the body, lactic acid will be gathered in the legs, especially the relatively more developed muscle zone, and lead to the soreness of the calf stomach. Secondly, heat cramps, heat exhaustion and pyrexia during heat stroke will occur at the same time as rhabdomyolysis, which will also cause soreness in the calf tummy at night while sleeping. Third, the incorrect way and method of exercise can also lead to excessive accumulation of creatine kinase in the body resulting in sore calves. Fourth, the calf contact with a large number of allergens history, resulting in local skin allergy, will appear soreness and pain in the calf stomach. Fifth, infections such as retrograde bloodstream infection, peripheral infection, dermatitis or cellulitis can also cause soreness and pain in the calf tummy while sleeping.