The cost of root canal treatment for a tooth is directly related to regional differences, the treatment technique adopted by the hospital, and the number of root canals in the tooth. In general, in third and fourth tier cities, the cost of root canal treatment for a single tooth is about$300 for manual instrumentation and about$500 for mechanical instrumentation. For double root canal treatment of premolar teeth, the cost is about 600 RMB for manual instrumentation and 1000 RMB for machine instrumentation. In the case of molar teeth, the manual instruments are about 1000 RMB, and the mechanical instruments are usually about 2000 RMB. However, in first-tier and second-tier cities, it is usually partly increased than in third-tier and fourth-tier cities.