Herpes cheilitis usually does not require oral cephalosporin because most cheilitis is a viral infection, seen in coxsackie group A viruses, which are more common in children. But nowadays, mixed infections are also very common. Therefore, the patient first needs to go to the hospital for blood tests. If the patient has elevated white blood cells and neutrophils, the patient is considered to have a bacterial infection. Oral cephalosporin anti-inflammatory drugs, such as cefixime and amoxicillin, are needed for treatment. If the patient’s lymphocytes are elevated, it is considered a viral infection that does not require any oral medication and can heal on its own. However, patients need to closely monitor the patient’s temperature during treatment. If the temperature rises above 38.5 degrees, treatment with antipyretic drugs is necessary. Oral ibuprofen extended-release tablets and Merlin pellets can be taken for antipyretic treatment. During the treatment period, the patient needs to drink more water and pay more attention to rest and can be cured.