Patients with renal insufficiency can’t take colchicine, which is a kind of uric acid-lowering drug and is more effective in treating gout. And the side effects of colchicine are large, which can cause liver and kidney damage as well as gastrointestinal reactions. Patients with renal insufficiency have impaired metabolism of colchicine, which can cause the accumulation of the drug in the body, and the accumulation of the drug in turn can aggravate the damage of renal function, so patients with renal insufficiency can not take colchicine. If patients with renal insufficiency have gouty attacks, they can apply hormones such as prednisone for short-term treatment, and if the pain is relieved, they can apply drugs such as febuxostat to control uric acid and alleviate gouty attacks in patients with renal insufficiency.