Babinski’s sign is a pathological reflex, and its positive manifestation is dorsiflexion of the bunion and fan spread of the remaining four toes. Babinski’s sign is one of the most common signs in neurology and one of the most reliable signs of injury to the pyramidal fasciculus, which can be examined clinically to determine the function of the pyramidal system and the extrapyramidal system. Positive Babinski’s sign can also occur in infants before the development of the pyramidal fasciculus is complete, and in adults in deep sleep and under anesthesia. Babinski’s sign generally appears as damage to any part of the motor areas of the cerebral cortex, and its downward projection to the corticospinal tract. Its clinical significance: Babinski’s sign is the single most important sign in the presence of damage to the pyramidal tract. The presence of this sign in children over two years of age and in adults has definite pathological significance.