Thighs have uncomfortable indescribable feeling, the possible causes are herniated disc compression of nerves, muscle strain, chronic inflammation, peripheral neuritis. 1. Herniated disc: If a patient has a herniated lumbar disc or a herniated cervical disc, and if the protruding nucleus pulposus compresses the peripheral nerves, it may lead to abnormal sensory nerves in the limbs, and there may be numbness, fatigue, and acidity, but due to the unclear localization, the patient may feel uncomfortable but not be able to say what symptoms he or she is experiencing. 2. Muscle strain or chronic inflammation: if the patient has been doing strenuous exercise of both lower limbs for a long time, such as playing soccer, basketball, mountain climbing, long jumping, etc., the muscles of the thighs may suffer from chronic inflammation or muscle strain due to long-term strenuous activities, which may lead to the symptoms of discomfort in the thighs. 3. Peripheral neuritis: Peripheral neuritis is common in diseases such as history of diabetes, heavy metal poisoning, uremia, hereditary peroneal muscular atrophy, etc. Due to the damage of peripheral nerves, sensory abnormalities can occur, which in turn lead to the symptom of discomfort in the legs. Appearance of thighs have uncomfortable unable to say feeling, it is recommended to go to the regular hospital in time to find out the cause, timely treatment.