The difference between herpes and HFMD lies in their respective concepts, causes, and symptoms. 1. Concept: herpes refers to a large group of diseases, which are most commonly seen clinically in chickenpox, herpes zoster, herpes gingivostomatitis, genital herpes, oral and labial herpes and other types. And hand, foot and mouth disease belongs to an acute febrile rash infectious diseases, purely and specifically refers to a disease. 2. Causes: Herpes is caused by human herpes virus infection. Hand, foot and mouth disease is caused by enterovirus infections, such as enterovirus 71, coxsackievirus A16 and so on. 3. Symptoms: The clinical symptoms of herpes are mainly manifested as single or clustered blisters or pustules on the affected area, accompanied by fever, pain, swollen lymph nodes, sore throat and other symptoms, and the accompanying symptoms are different for different types of herpes. However, HFMD is preceded by symptoms such as low-grade fever, headache, and loss of appetite, and there will be a red blotchy rash on the mouth and hands, which then develops into small blisters. To summarize, herpes is not the same as HFMD, and patients are advised to visit a hospital to have their condition diagnosed by a professional doctor.