Sleeping up with a sore throat may be related to acute upper respiratory tract infection, sleep apnea hypoventilation syndrome, reflux pharyngitis and so on. 1. Acute upper respiratory tract infection: In the early stage of acute upper respiratory tract infection, viral infection may cause pharyngeal inflammation, which is manifested as redness, swelling, and pain in the pharynx, resulting in a sore throat after getting up from sleep. In the later stage, bacterial infection may complicate, which may further aggravate the pain symptoms. 2. Sleep apnea syndrome: patients with sleep apnea hypoventilation syndrome will open their mouths to breathe at night, due to the role of airflow in the oral cavity will cause mucus evaporation in the pharyngeal cavity, at this time, the pharyngeal mucous membrane due to dryness, congestion will produce pain. 3. Reflux pharyngitis: when suffering from reflux pharyngitis, due to sleep at night in the lying position, stomach acid is more likely to reflux, due to acidic stimulation, pharyngeal mucosa congestion, redness and swelling caused by sore throat. So if you have the symptom of sleeping up with a sore throat, it is recommended to consult a doctor in time to clarify the cause of the disease, and under the guidance of the doctor to carry out regular treatment.