In the third trimester of pregnancy, if there is persistent pain in the abdomen, we should pay attention to any fetal abnormalities because the fetus is not stable in the third trimester and needs further examination by the obstetrics and gynecology department. Secondly, we should pay attention to the presence of appendicitis, because the pain in the early stage of appendicitis is often around the navel, and later it will shift to the right lower abdomen, the pain is persistent, there will be pressure pain and rebound pain in the right lower abdomen, and blood sampling will reveal an increase in the ratio of white blood cells and neutrophils. If the pain is constant on one side, it is important to rule out the presence of ureteral stones, which are often persistent and often unbearable. Gynecological problems, such as ovarian and fallopian tube abnormalities, should also be ruled out, and further ultrasound is needed to rule them out before treating the relevant aspects.