Commonly used drugs in SLE drug therapy include non-steroidal anti-inflammatory drugs (NSAIDs), anti-malarials, glucocorticoids, immunosuppressants, biologics, immunoglobulins, anticoagulants, and antihypertensive drugs, etc. The purpose of treatment is to control disease activity and relieve clinical symptoms. At present, SLE cannot be cured or eradicated, and the purpose of treatment is to control the disease activity and alleviate the clinical symptoms of patients. Commonly used drugs include non-steroidal anti-inflammatory drugs (NSAIDs), anti-malarial drugs, glucocorticosteroids, immunosuppressant drugs, biologics, immunoglobulins, anticoagulants, antihypertensives, and so on, and the formulation of a specific treatment plan needs to be made based on the specific condition of the patient, individual constitution, and other factors. The representative drugs of NSAIDs are diclofenac, acetaminophen, etc., anti-malarial drugs are mainly hydroxychloroquine, immunosuppressants include cyclophosphamide, azathioprine, etc., biologics such as belimumab, etc., anticoagulants such as rivaroxaban, etc., antihypertensive drugs such as valsartan, etc., SLE with different conditions and symptoms needs to be treated with different drug treatment programs. Different conditions and different symptoms require different drug treatment programs. Drugs should be used under the guidance of a physician, and it is recommended that SLE patients go to the rheumatology and immunology department of a regular hospital for a detailed consultation, and do not take drugs on their own.