Recently, 52-year-old Ms. Fan was discharged from the ICU ward with a big smile on her face. Although Ms. Fan is only 52 years old, she has been suffering from the disease for many years. She was diagnosed with allergic asthma more than 10 years ago, and her cough, phlegm and shortness of breath became more obvious in the past 9 years, especially in winter every year, which was a test for Ms. Fan, and she was repeatedly hospitalized for years. 3 days ago, Ms. Fan’s condition suddenly worsened, with fainting 3 times, nausea and vomiting, and her condition still did not improve after several days of treatment at Shanda First Hospital, and finally a chest X-ray revealed lung shadows and considered tuberculosis. Seeing that Ms. Fan’s shortness of breath was getting worse and worse, and she could not sleep, eat, and even speak with increasing difficulty, her family was so anxious that they came to our hospital with the intention of giving it a try. Ms. Fan’s appearance immediately drew the attention of Director Zhao Aibin of the Department of Critical Care Medicine of our hospital. With years of clinical experience, he immediately decided that the patient was in the state of asthma attack, and it was urgent to improve the patient’s current symptoms; if it went on for a long time, various complications such as respiratory failure, pneumothorax and multiple organ insufficiency (MODS) might endanger the patient’s life at any time. Director Zhao saw in his eyes and heart, the conventional treatment Shanda First Hospital has done a good job, but ineffective, the patient’s symptoms are getting more and more serious. Tracheal intubation with invasive ventilator therapy can quickly improve the patient’s symptoms, but for patients in rural families, medical costs are so large that patients often give up treatment. What to do? With the experience of successful use of non-invasive ventilators in our hospital during the SARS and H1N1 epidemics, non-invasive ventilators may be the last effort we can make before tracheal intubation. However, there are few studies on the use of non-invasive ventilators in asthma treatment in China, and there is no unified standard yet, especially for this kind of severe patients who are difficult to cooperate with. We had to try anyway. Director Zhao stood beside the patient with a calm face, holding the mask of the non-invasive ventilator over the patient’s mouth and nose, “Don’t be afraid, I will stand beside you, you can tell me anytime if you are uncomfortable. While patiently comforting her, Director Zhao carefully adjusted the ventilator parameters and stood in front of the bed for four or five hours until the patient adapted to the non-invasive ventilator and her symptoms were significantly relieved. The partial pressure of oxygen rose from 30 mmHg at the time of admission to 70 mmHg before he was relieved to leave work, which was already more than 11:00 pm. The next day, Director Zhao organized another department-wide discussion on the treatment of this difficult-to-treat severe asthma, not only to determine a more effective treatment plan, but also as a rare learning opportunity for the young residents. After four days and nights of intensive resuscitation, the patient was finally released from danger. The patient was discharged from the hospital 8 days later, thanks to the excellent medical skills and attentive care of the medical staff. Since its establishment at the beginning of this year, the Department of Intensive Care Medicine of Taiyuan Fourth People’s Hospital has successfully rescued many patients with acute and critical illnesses such as respiratory failure, infectious shock, MODS, severe tuberculous meningitis and tuberculous intestinal obstruction. The success of this rescue has accumulated valuable experience for the treatment of severe asthma in our hospital, and saved the lives of patients at the same time.