Botulinum toxin can inhibit the nerve endings of the muscles around the marionette lines, blocking the information conduction, thus causing flaccid paralysis of the muscles at the marionette lines, which can weaken the contraction of the descending angle of the mouth muscle and cervical broad muscle, so that the patient’s angle of the mouth in a state of repose is lifted up, the therapeutic effect is more desirable. Botulinum toxin to marionette lines is relatively safe compared to other surgical methods, but there are also the following surgical risks: 1, granulomas and other side effects: less common and more difficult to treat, may require surgical resection; 2, local bruising: manifested as skin bruising, less frequent, lasts for 1-2 weeks or so can disappear on their own; 3, botulinum toxin to the nerve is very obvious, may lead to numbness of the nerves, the serious case will damage the facial nerve And long-term use is prone to premature aging symptoms, it is recommended to be injected 2-3 times a year. If short-term frequent injection is easy to produce antibodies, resulting in poor results of re-injection; 5, botulinum toxin poisoning: toxic shock needs to be rescued, local skin allergy phenomenon is rare; 6, bilateral power asymmetry, resulting in crooked corners of the mouth. After injection of botulinum toxin, patients should pay attention to drink more water to prevent the role of botulinum toxin toxicity. If toxic reactions such as body weakness, fever, and generalized itching occur, it is important to go to the hospital in time for examination and treatment according to the doctor’s instructions.