Taking 2 capsules of magnesium valproate a day for a long period of time can be harmful. Magnesium valproate is used in the treatment of all types of epilepsy and also in the treatment of manic episodes in bipolar disorder. Used to treat the above conditions, patients often need to take the drug for a long period of time. Long-term use of magnesium valproate has certain toxic side effects, commonly nausea, vomiting, fear of food, diarrhea and so on. A few patients may experience drowsiness, tremor, ataxia, hair loss, abnormal excitement and irritability. Long-term use of magnesium valproate will occasionally see allergic rash, thrombocytopenia or platelet aggregation inhibition causing abnormal bleeding, leukopenia or toxic liver damage. If there are serious adverse reactions such as impaired consciousness, abnormal liver function, pancreatitis, etc., the drug should be discontinued. Although magnesium valproate has certain side effects, but for patients, its benefits outweigh the disadvantages, the treatment process need to pay attention to drug-related adverse reactions. Serious adverse reactions are recommended to stop the drug in time, go to the hospital, follow the doctor’s instructions, and deal with it accordingly.